Author: Shrock, Ellen; Fujimura, Eric; Kula, Tomasz; Timms, Richard T.; Lee, I-Hsiu; Leng, Yumei; Robinson, Matthew L.; Sie, Brandon M.; Li, Mamie Z.; Chen, Yuezhou; Logue, Jennifer; Zuiani, Adam; McCulloch, Denise; Lelis, Felipe J. N.; Henson, Stephanie; Monaco, Daniel R.; Travers, Meghan; Habibi, Shaghayegh; Clarke, William A.; Caturegli, Patrizio; Laeyendecker, Oliver; Piechocka-Trocha, Alicja; Li, Jonathan Z.; Khatri, Ashok; Chu, Helen Y.; Villani, Alexandra-Chloé; Kays, Kyle; Goldberg, Marcia B.; Hacohen, Nir; Filbin, Michael R.; Yu, Xu G.; Walker, Bruce D.; Wesemann, Duane R.; Larman, H. Benjamin; Lederer, James A.; Elledge, Stephen J.
Title: Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity Cord-id: ftjrg3dk Document date: 2020_11_27
ID: ftjrg3dk
Snippet: Understanding humoral responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical for improving diagnostics, therapeutics, and vaccines. Deep serological profiling of 232 coronavirus disease 2019 (COVID-19) patients and 190 pre–COVID-19 era controls using VirScan revealed more than 800 epitopes in the SARS-CoV-2 proteome, including 10 epitopes likely recognized by neutralizing antibodies. Preexisting antibodies in controls recognized SARS-CoV-2 ORF1, whereas only COVI
Document: Understanding humoral responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical for improving diagnostics, therapeutics, and vaccines. Deep serological profiling of 232 coronavirus disease 2019 (COVID-19) patients and 190 pre–COVID-19 era controls using VirScan revealed more than 800 epitopes in the SARS-CoV-2 proteome, including 10 epitopes likely recognized by neutralizing antibodies. Preexisting antibodies in controls recognized SARS-CoV-2 ORF1, whereas only COVID-19 patient antibodies primarily recognized spike protein and nucleoprotein. A machine learning model trained on VirScan data predicted SARS-CoV-2 exposure history with 99% sensitivity and 98% specificity; a rapid Luminex-based diagnostic was developed from the most discriminatory SARS-CoV-2 peptides. Individuals with more severe COVID-19 exhibited stronger and broader SARS-CoV-2 responses, weaker antibody responses to prior infections, and higher incidence of cytomegalovirus and herpes simplex virus 1, possibly influenced by demographic covariates. Among hospitalized patients, males produce stronger SARS-CoV-2 antibody responses than females.
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