Author: Linlin Zhang; Daizong Lin; Yuri Kusov; Yong Nian; Qingjun Ma; Jiang Wang; Albrecht von Brunn; Pieter Leyssen; Kristina Lanko; Johan Neyts; Adriaan de Wilde; Eric J. Snijder; Hong Liu; Rolf Hilgenfeld
Title: Alpha-ketoamides as broad-spectrum inhibitors of coronavirus and enterovirus replication Document date: 2020_2_10
ID: 7n8p9okf_81
Snippet: Synthesis of alcohols 7 (general procedure). Compound 6 (1.1 mmol) was dissolved in methanol (40 mL), then NaBH4 (0.34 g, 8.8 mmol) was added under ambient conditions. The reaction mixture was stirred at 20 o C for 2 h. Then the reaction was quenched with water (30 mL). The suspension was extracted with ethyl acetate. The organic layers were combined, dried, and filtered. The filtrate was evaporated to dryness and could be used for the next step .....
Document: Synthesis of alcohols 7 (general procedure). Compound 6 (1.1 mmol) was dissolved in methanol (40 mL), then NaBH4 (0.34 g, 8.8 mmol) was added under ambient conditions. The reaction mixture was stirred at 20 o C for 2 h. Then the reaction was quenched with water (30 mL). The suspension was extracted with ethyl acetate. The organic layers were combined, dried, and filtered. The filtrate was evaporated to dryness and could be used for the next step without further purification (46-85% yield).
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