Selected article for: "permission allow and protease drug"
Author: Yan Gao; Liming Yan; Yucen Huang; Fengjiang Liu; Yao Zhao; Lin Cao; Tao Wang; Qianqian Sun; Zhenhua Ming; Lianqi Zhang; Ji Ge; Litao Zheng; Ying Zhang; Haofeng Wang; Yan Zhu; Chen Zhu; Tianyu Hu; Tian Hua; Bing Zhang; Xiuna Yang; Jun Li; Haitao Yang; Zhijie Liu; Wenqing Xu; Luke W. Guddat; Quan Wang; Zhiyong Lou; Zihe Rao
Title: Structure of RNA-dependent RNA polymerase from 2019-nCoV, a major antiviral drug target
  • Document date: 2020_3_17
    • ID: glfxrla9_11
    Snippet: The rapid global spread of 2019-nCoV has emphasized the need for the development of new coronavirus vaccines and therapeutics. The viral polymerase nsp12 looks an excellent target for new therapeutics, especially given that lead inhibitors already exist in the form of compounds such 20 as remdesivir. This target, in addition to other promising drug targets such as the main protease, whose structure was recently determined by our group (18) in com.....
    Document: The rapid global spread of 2019-nCoV has emphasized the need for the development of new coronavirus vaccines and therapeutics. The viral polymerase nsp12 looks an excellent target for new therapeutics, especially given that lead inhibitors already exist in the form of compounds such 20 as remdesivir. This target, in addition to other promising drug targets such as the main protease, whose structure was recently determined by our group (18) in complex with an inhibitor (19, 20) will support the development of a cocktail of anti-coronavirus treatments that potentially can be used for the discovery of broad-spectrum antivirals. The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.16.993386 doi: bioRxiv preprint Acknowledgments: We would like to pay an exceptional tribute to ShanghaiTech University and their administrative team, as well as the Bio-Electron Microscopy Facility for their great care and support to our research team to enable us to carry out this research in a safe and healthy environment. It would have been impossible for us to attain this achievement without their tremendous efforts in the last two months during the nCoV-19 pandemic. We also would like to 5 convey our special thanks to Tsinghua University for their exceptional permission to allow five of Z. R.'s students to go back to the laboratory to prepare the protein samples for this study. We also must express our gratitude to the campus service team of ShanghaiTech University scientific research platform of Shanghai Institute for Advanced Immunochemical Studies (SIAIS), and National Center for Protein Science Shanghai (NCPSS), as well as all the manager and technician

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