Author: Ramasubramanian Sundaramoorthy; Amanda L. Hughes; Hassane El-Mkami; David Norman; Tom Owen-Hughes
Title: Structure of the chromatin remodelling enzyme Chd1 bound to a ubiquitinylated nucleosome Document date: 2018_3_30
ID: ct2zhauz_11
Snippet: The orientation of the DNABD is critical in determining the extent of DNA unwrapping. The only contacts detected between the DNABD and the remainder of Chd1 are contacts with the chromodomains (Figure 2 ). The first of these is the interaction between K329 of chromodomain II and D1201 off two turns of nucleosomal DNA, a process that likely requires substantial force (Hall et al., 2009; Meng et al., 2015) . As a result it is somewhat surprising th.....
Document: The orientation of the DNABD is critical in determining the extent of DNA unwrapping. The only contacts detected between the DNABD and the remainder of Chd1 are contacts with the chromodomains (Figure 2 ). The first of these is the interaction between K329 of chromodomain II and D1201 off two turns of nucleosomal DNA, a process that likely requires substantial force (Hall et al., 2009; Meng et al., 2015) . As a result it is somewhat surprising that the area of contact between the chromodomains and DNABD is so small. It is possible that additional regions of Chd1 including the Nterminus that is not resolved in the density map also contribute to this interaction as suggested by previous studies of Chd1 proteins (Liu et al., 2015; Zhou et al., 2018 )(Sundaramoorthy et al., 2017 .
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