Selected article for: "liver kidney heart and lung kidney low"
Author: Ao-Xiang Guo; Jia-Jia Cui; Qian-Ying OuYang; Li He; Cheng-Xian Guo; Ji-Ye Yin
Title: The clinical characteristics and mortal causes analysis of COVID-19 death patients
  • Document date: 2020_4_15
    • ID: dtlwjndn_40
    Snippet: In order to explain the clinical features of death patients, we combined the clinical features with the expression of ACE2 and TMPRSS2. TMPRSS2 had a high expression in more organs such as lung, liver and kidney, but had a low expression in heart. ACE2 was highly expressed in heart. Therefore, the key target controlling the invasion of SARS-CoV-2 in different organs may be different. And TMPRSS2 seems had a wider expression and may be more import.....
    Document: In order to explain the clinical features of death patients, we combined the clinical features with the expression of ACE2 and TMPRSS2. TMPRSS2 had a high expression in more organs such as lung, liver and kidney, but had a low expression in heart. ACE2 was highly expressed in heart. Therefore, the key target controlling the invasion of SARS-CoV-2 in different organs may be different. And TMPRSS2 seems had a wider expression and may be more important for patients' infection. Besides, a recent study has reported that a TMPRSS2 inhibitor approved for clinical use could block SARS-CoV-2 from entering cells and might constitute a treatment option [4].

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