Author: Jieyu Guo; Xiangxiang Wei; Qinhan Li; Liliang Li; Zhaohua Yang; Yu Shi; Yue Qin; Xinyue Zhang; Xinhong Wang; Xiuling Zhi; Dan Meng
Title: Single-cell RNA Analysis on ACE2 Expression Provides Insight into SARS-CoV-2 Blood Entry and Heart Injury Document date: 2020_4_4
ID: in3b1nzv_15
Snippet: Moreover, these cells highly expressed chemokine (CXCL12, CCL2) and integrin subunit (ITGA1, ITGA7) (Fig. S3C) , which may participate in viral infection, postinfection immune response, migration, and adhesion of immune cells. GO and KEGG analysis of ACE2-expressing arterial vascular cells in failed heart also suggested that these cells were highly correlated with virus response and infectious diseases (Fig. S4A-S4B ). Unlike normal heart, these .....
Document: Moreover, these cells highly expressed chemokine (CXCL12, CCL2) and integrin subunit (ITGA1, ITGA7) (Fig. S3C) , which may participate in viral infection, postinfection immune response, migration, and adhesion of immune cells. GO and KEGG analysis of ACE2-expressing arterial vascular cells in failed heart also suggested that these cells were highly correlated with virus response and infectious diseases (Fig. S4A-S4B ). Unlike normal heart, these cells in failed heart expressed some regulators of monocyte and B cell differentiation, such as SOX4 and MEF2C (Fig. S4C) , which might be related to immune response and inflammation.
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