Author: Jieyu Guo; Xiangxiang Wei; Qinhan Li; Liliang Li; Zhaohua Yang; Yu Shi; Yue Qin; Xinyue Zhang; Xinhong Wang; Xiuling Zhi; Dan Meng
Title: Single-cell RNA Analysis on ACE2 Expression Provides Insight into SARS-CoV-2 Blood Entry and Heart Injury Document date: 2020_4_4
ID: in3b1nzv_3
Snippet: ACE2 was shown to be present in human lung alveolar epithelial cells 6 . Analysis of single-cell RNA-Seq (scRNA-seq) data in normal human lung tissues demonstrated that ACE2 is mainly expressed in type II alveolar cells (AT2) 7 . The pathological investigation of COVID-19 fatal cases showed exudation and hemorrhage, epithelium injuries, infiltration of macrophages, and fibrosis in the lungs 8 . Pulmonary fibrosis is not only due to that SARS-CoV-.....
Document: ACE2 was shown to be present in human lung alveolar epithelial cells 6 . Analysis of single-cell RNA-Seq (scRNA-seq) data in normal human lung tissues demonstrated that ACE2 is mainly expressed in type II alveolar cells (AT2) 7 . The pathological investigation of COVID-19 fatal cases showed exudation and hemorrhage, epithelium injuries, infiltration of macrophages, and fibrosis in the lungs 8 . Pulmonary fibrosis is not only due to that SARS-CoV-2 directly attacking the lung as its target organ, while the activation of cytokine storm in COVID-19 patients also contributes 9, 10 . A retrospective cohort study indicates that patients with chronic obstructive pulmonary disease (COPD) and bilateral pulmonary infiltration are associated with higher mortality 11 . It may be due to the change of ACE2 gene expression profile in lung tissues in patients with lung diseases, which makes these patients more susceptible to SARS-CoV-2 infection, but the cell-type specific expression change of ACE2 in healthy populations and patients with underlying lung diseases has not been reported.
Search related documents:
Co phrase search for related documents- cell type and cohort study: 1, 2, 3, 4, 5
- cell type and COPD pulmonary disease: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- cell type and cytokine storm: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16
- cell type and epithelial cell: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74
- cell type and epithelium injury: 1
- cell type and expression change: 1, 2, 3, 4, 5, 6, 7
- cell type and gene expression: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79
- cell type and gene expression profile: 1, 2, 3, 4, 5
- cell type and high mortality: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17
- cell type and human lung: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65
- cell type and human lung tissue: 1, 2, 3, 4, 5, 6, 7, 8, 9
- cell type and lung disease: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27
- cell type and lung tissue: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34
- cell type and macrophage infiltration: 1, 2, 3
- cell type and obstructive COPD pulmonary disease: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- cell type and organ target: 1, 2, 3
- cell type and pathological investigation: 1
- cell type and pulmonary disease: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23
- cell type and pulmonary fibrosis: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17
Co phrase search for related documents, hyperlinks ordered by date