Selected article for: "influenza epidemiology and pandemic virus"
Author: Zhang, Yong-Hong; Zhao, Yan; Li, Ning; Peng, Yan-Chun; Giannoulatou, Eleni; Jin, Rong-Hua; Yan, Hui-Ping; Wu, Hao; Liu, Jin-Hua; Liu, Ning; Wang, Da-Yan; Shu, Yue-Long; Ho, Ling-Pei; Kellam, Paul; McMichael, Andrew; Dong, Tao
Title: Interferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with severe influenza in Chinese individuals
  • Cord-id: hor76pqs
  • Document date: 2013_1_29
    • ID: hor76pqs
    Snippet: The SNP rs12252-C allele alters the function of interferon-induced transmembrane protein-3 increasing the disease severity of influenza virus infection in Caucasians, but the allele is rare. However, rs12252-C is much more common in Han Chinese. Here we report that the CC genotype is found in 69% of Chinese patients with severe pandemic influenza A H1N1/09 virus infection compared with 25% in those with mild infection. Specifically, the CC genotype was estimated to confer a sixfold greater risk
    Document: The SNP rs12252-C allele alters the function of interferon-induced transmembrane protein-3 increasing the disease severity of influenza virus infection in Caucasians, but the allele is rare. However, rs12252-C is much more common in Han Chinese. Here we report that the CC genotype is found in 69% of Chinese patients with severe pandemic influenza A H1N1/09 virus infection compared with 25% in those with mild infection. Specifically, the CC genotype was estimated to confer a sixfold greater risk for severe infection than the CT and TT genotypes. More importantly, because the risk genotype occurs with such a high frequency, its effect translates to a large population-attributable risk of 54.3% for severe infection in the Chinese population studied compared with 5.4% in Northern Europeans. Interferon-induced transmembrane protein-3 genetic variants could, therefore, have a strong effect of the epidemiology of influenza in China and in people of Chinese descent.

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