A Comprehensive Review of COVID-19 Associated Neurological Manifestations.

Aggarwal, Chander Shekher; Walser, Sarah; Bhandari, Abani; Garg, Nikita; McClafferty, Brendan; Ramgobin, Devyani; Golamari, Reshma; Sahu, Nitasa; Kumar, Ashutosh; Jain, Rohit

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing COVID-19 utilizes the angiotensin-converting enzyme 2 (ACE-2) receptor of cells in order to gain entry and continue infection. Recent literature has focused on acute respiratory distress syndrome (ARDS) and other associated pulmonary complications; however, only a scarce amount of literature exists on neurological complications. Such complications also pose a high morbidity in these patients. The exact pathogenesis of nervous system involvement by COVID-19 still remains poorly understood. The aim of this article is to review the neurological symptoms seen in COVID-19 infection and discuss the probable pathogenesis, management and outcome of associated neurological complications.