Author: Wenhao Dai; Bing Zhang; Xia-Ming Jiang; Haixia Su; Jian Li; Yao Zhao; Xiong Xie; Zhenming Jin; Jingjing Peng; Fengjiang Liu; Chunpu Li; You Li; Fang Bai; Haofeng Wang; Xi Cheng; Xiaobo Cen; Shulei Hu; Xiuna Yang; Jiang Wang; Xiang Liu; Gengfu Xiao; Hualiang Jiang; Zihe Rao; Leike Zhang; Yechun Xu; Haitao Yang; Hong Liu
Title: Structure-Based Design, Synthesis and Biological Evaluation of Peptidomimetic Aldehydes as a Novel Series of Antiviral Drug Candidates Targeting the SARS-CoV-2 Main Protease Document date: 2020_3_28
ID: b4joa5tx_32
Snippet: The in vivo toxicity study (Table S4 ) of 11a have been carried out on SD rats and Beagle dogs. The acute toxicity of 11a was conducted on SD rats, and no SD rats died after receiving 40 mg/kg via intravenous drip administration. When the dosage was raised to 60 mg/kg, one of four SD rats was died. The dose range toxicity study of 11a was conducted for seven days in the dosing level at 2, 6, 18 mg/kg on SD rats and at 10-40 mg/kg on Beagle dogs, .....
Document: The in vivo toxicity study (Table S4 ) of 11a have been carried out on SD rats and Beagle dogs. The acute toxicity of 11a was conducted on SD rats, and no SD rats died after receiving 40 mg/kg via intravenous drip administration. When the dosage was raised to 60 mg/kg, one of four SD rats was died. The dose range toxicity study of 11a was conducted for seven days in the dosing level at 2, 6, 18 mg/kg on SD rats and at 10-40 mg/kg on Beagle dogs, once daily dosing (QD), by intravenous drip, all animals were clinically observed once a day at least and no obvious toxicity was observed in each group. The results show 11a with low toxicity on rats and dogs. Discussion author/funder. All rights reserved. No reuse allowed without permission.
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