Author: Bishajit Sarkar; Md. Asad Ullah; Fatema Tuz Johora; Masuma Afrin Taniya; Yusha Araf
Title: The Essential Facts of Wuhan Novel Coronavirus Outbreak in China and Epitope-based Vaccine Designing against COVID-19 Document date: 2020_2_11
ID: 7vrm081c_3
Snippet: To date, there is no effective antiviral therapies that can combat the Coronavirus infections and hence the treatments are only supportive. Use of Interferons in combination with Ribavirin is somewhat effective. However, the effectiveness of combined remedy needs to be further evaluated [95] . This experiment is carried out to design novel epitope-based vaccine against four proteins of SARS-CoV-2 i.e., nucleocapsid phosphoprotein which is respons.....
Document: To date, there is no effective antiviral therapies that can combat the Coronavirus infections and hence the treatments are only supportive. Use of Interferons in combination with Ribavirin is somewhat effective. However, the effectiveness of combined remedy needs to be further evaluated [95] . This experiment is carried out to design novel epitope-based vaccine against four proteins of SARS-CoV-2 i.e., nucleocapsid phosphoprotein which is responsible for genome packaging and viral assembly [96] ; surface glycoprotein that is responsible for membrane fusion event during viral entry [97] [98] ; ORF3a protein that is responsible for viral replication, characterized virulence, viral spreading and infection [99] and membrane glycoprotein which mediates the interaction of virions with cell receptors [100] using the approaches of reverse vaccinology.
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