The Essential Facts of Wuhan Novel Coronavirus Outbreak in China and Epitope-based Vaccine Designing against COVID-19

Bishajit Sarkar; Md. Asad Ullah; Fatema Tuz Johora; Masuma Afrin Taniya; Yusha Araf

The molecular dynamics (MD) simulation study was of the best selected vaccine construct was carried out using the online MD simulation tool, iMODS (http://imods.chaconlab.org/). It is a fast, online, user-friendly and effective molecular dynamics simulation server that predicts the deformability, B-factor (mobility profiles), eigenvalues, variance, co-variance map and elastic network of the protein complex. For a protein complex, the stability depends on the ability to deform at each of its amino acids. The eigenvalue represents the motion stiffness of the protein complex and the lower eigenvalue represents easy deformability of the complex. The server also determines and measures the protein flexibility [165] - [169] .