International registry of dermatological manifestations secondary to COVID‐19 infection in 347 Hispanic patients from 25 countries

Ocampo‐Candiani, Jorge; Ramos‐Cavazos, Cesar Jair; Arellano‐Mendoza, Maria Ivonne; Arenas‐Guzmán, Roberto; Beirana‐Palencia, Angélica; Salmon‐Demongin, Alfredo; Welsh‐Hernández, Esperanza; Cabo, Horacio A.; Gómez‐Flores, Minerva; Dominguez‐Cherit, Judith; Criado, Paulo Ricardo; Castro‐López, Helena; Alfaro‐Sánchez, Abraham Benjamin; García‐Vargas, Alejandro; Cohen‐Sabban, Emilia N.; del Solar, Manuel; Fich, Félix; Galimberti, Gastón; Gatti, Carlos Fernando; López‐Estebaranz, José Luis; Lupi, Omar; Olmos‐Pérez, Miguel; Pérez‐Alfonzo, Ricardo

BACKGROUND: The infection by coronavirus disease 2019 (COVID‐19) has been associated with multiple cutaneous manifestations, although characterization of them in Hispanic patients with darker skin phototypes is lacking. The objective of this study is to characterize the clinical dermatological manifestations associated with COVID‐19 infection in cases with few or without general symptoms in patients from Latin America. METHODS: Cross‐sectional study using a questionnaire that was made for health professionals (physicians with a specialty in dermatology) to investigate dermatological lesions associated with COVID‐19 infection in patients from 25 countries of Latin America. The survey was active from June 9 to July 30, 2020. RESULTS: In this study, information was collected from a total of 347 patients. We found a female gender predominance: 179/347 (51.6%). The mean age at presentation was 40.87 years. The most frequent dermatological manifestations were maculopapular rash and urticarial lesions, followed by papulovesicular lesions, vesicular lesions, chilblain‐like lesions, papular lesions, ecchymosis, petechial purpura, pityriasis rosea‐like lesions, pruritus, palmoplantar dysesthesias, transient livedo, acral necrosis, palpable purpura, livedo racemosa, and retiform purpura. As far as we know, there are no previous reports of pruritus and palmoplantar dysesthesias. CONCLUSIONS: This registry emphasizes skin manifestations as an important criterion for establishing the diagnosis of COVID‐19 infection in Latin American countries. This information will be useful for the early identification of suspected cases by health professionals (dermatologists and nondermatologists) and will allow contact tracing to mitigate the impact on health systems at different levels.