Author: Aaron S. Mendez; Carolin Vogt; Jens Bohne; Britt A. Glaunsinger
Title: Site specific target binding controls RNA cleavage efficiency by the Kaposi’s sarcoma-associated herpesvirus endonuclease SOX Document date: 2018_5_13
ID: 298cbr1x_50
Snippet: (E) EMSAs were used to determine percent binding of 5' 32 P-labeled LIMD1 54 RNA probe to WT SOX, P176S, and F179A. Curves were fit to a single binding model from three independent measurements. The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It . https://doi.org/10.1101/320929 doi: bioRxiv preprint SOX is able to distinguish mRNA from other types of RNA in cells by an as yet unknown mechanism. Subsequen.....
Document: (E) EMSAs were used to determine percent binding of 5' 32 P-labeled LIMD1 54 RNA probe to WT SOX, P176S, and F179A. Curves were fit to a single binding model from three independent measurements. The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It . https://doi.org/10.1101/320929 doi: bioRxiv preprint SOX is able to distinguish mRNA from other types of RNA in cells by an as yet unknown mechanism. Subsequently, it endonucleolytically cleaves its targets at specific sites, whereupon the fragments are degraded by host exonucleases such as Xrn1 and Dis3L2.
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