Author: Yong Zhang; Wanjun Zhao; Yonghong Mao; Shisheng Wang; Yi Zhong; Tao Su; Meng Gong; Xiaofeng Lu; Jingqiu Cheng; Hao Yang
Title: Site-specific N-glycosylation Characterization of Recombinant SARS-CoV-2 Spike Proteins using High-Resolution Mass Spectrometry Document date: 2020_3_29
ID: 8xck5832_20
Snippet: Notably, a low ratio (~12%) of high-mannose glycans ubiquitously exist on human cell-expressed S protein (Fig. 3F ). The HIV envelope glycoprotein gp120 is heavily decorated with the immature intermediate, high-mannose glycans. The high-density glycans surrounding HIV glycoproteins limit the accessibility of glycan biosynthetic processing enzymes, terminating the synthesis of more complex end products(17, 24)......
Document: Notably, a low ratio (~12%) of high-mannose glycans ubiquitously exist on human cell-expressed S protein (Fig. 3F ). The HIV envelope glycoprotein gp120 is heavily decorated with the immature intermediate, high-mannose glycans. The high-density glycans surrounding HIV glycoproteins limit the accessibility of glycan biosynthetic processing enzymes, terminating the synthesis of more complex end products(17, 24).
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