Author: Yong Zhang; Wanjun Zhao; Yonghong Mao; Shisheng Wang; Yi Zhong; Tao Su; Meng Gong; Xiaofeng Lu; Jingqiu Cheng; Hao Yang
Title: Site-specific N-glycosylation Characterization of Recombinant SARS-CoV-2 Spike Proteins using High-Resolution Mass Spectrometry Document date: 2020_3_29
ID: 8xck5832_27
Snippet: In this study, we decoded a global and site-specific profile of N-glycosylation on SARS-CoV-2 S proteins expressed from insect and human cells, revealing a regular heterogeneity in N-glycan composition and site occupancy. All glycosites were conserved among the 753 public SARS-CoV-2 genome sequences. In conclusion, our data indicate that differential N-glycan occupancies among distinct host cells might help elucidate the infection mechanism and d.....
Document: In this study, we decoded a global and site-specific profile of N-glycosylation on SARS-CoV-2 S proteins expressed from insect and human cells, revealing a regular heterogeneity in N-glycan composition and site occupancy. All glycosites were conserved among the 753 public SARS-CoV-2 genome sequences. In conclusion, our data indicate that differential N-glycan occupancies among distinct host cells might help elucidate the infection mechanism and develop an effective vaccine and targeted drugs. Nevertheless, the implication of S protein site-specific N-glycosylation in immunogenicity, receptor binding, and viral infectivity should be investigated further. The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.28.013276 doi: bioRxiv preprint
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