Author: Chau, Nguyen Van Vinh; Nhan, Le Nguyen Thanh; Nguyet, Lam Anh; Tu, Nguyen Thi Kha; Hong, Nguyen Thi Thu; Man, Dinh Nguyen Huy; Ty, Dinh Thi Bich; Nhu, Le Nguyen Truc; Yen, Lam Minh; Khanh, Truong Huu; Quy, Du Tuan; Minh, Ngo Ngoc Quang; Ny, Nguyen Thi Han; Anderson, Danielle; Wang, Lin-Fa; van Doorn, H. Rogier; Hung, Nguyen Thanh; Thanh, Tran Tan; Thwaites, Guy; Van Tan, Le
Title: Absence of SARS-CoV-2 antibodies in pre-pandemic plasma from children and adults in Vietnam Cord-id: j5erjttt Document date: 2021_7_31
ID: j5erjttt
Snippet: We tested pre-pandemic (2015-2019) plasma samples from 148 Vietnamese children, and 100 Vietnamese adults at high risk of zoonotic infections, for antibodies against SARS-CoV-2 nucleocapsid and spike proteins. None was positive. The data thus demonstrated that there was no evidence of prior serological cross-reactivity with SARS-CoV-2 that might explain the low numbers of COVID-19 in Vietnam. Future studies should look at pre-existing B cell and T cell memory in pre-pandemic samples in Vietnam,
Document: We tested pre-pandemic (2015-2019) plasma samples from 148 Vietnamese children, and 100 Vietnamese adults at high risk of zoonotic infections, for antibodies against SARS-CoV-2 nucleocapsid and spike proteins. None was positive. The data thus demonstrated that there was no evidence of prior serological cross-reactivity with SARS-CoV-2 that might explain the low numbers of COVID-19 in Vietnam. Future studies should look at pre-existing B cell and T cell memory in pre-pandemic samples in Vietnam, which might further shed light on the pathogenesis of the infection.
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