Author: Hassan, Sk. Sarif; Ghosh, Shinjini; Attrish, Diksha; Choudhury, Pabitra Pal; Uversky, Vladimir N.; Uhal, Bruce D.; Lundstrom, Kenneth; Rezaei, Nima; Aljabali, Alaa A. A.; Seyran, Murat; Pizzol, Damiano; Adadi, Parise; Soares, Antonio; El-Aziz, Tarek Mohamed Abd; Kandimalla, Ramesh; Tambuwala, Murtaza; Azad, Gajendra Kumar; Sherchan, Samendra P.; Baetas-da-Cruz, Wagner; Takayama, Kazuo; Serrano-Aroca, Ãngel; Chauhan, Gaurav; Palu, Giorgio; Brufsky, Adam M.
Title: Possible transmission flow of SARS-CoV-2 based on ACE2 features Cord-id: jx69dzsx Document date: 2020_10_9
ID: jx69dzsx
Snippet: Angiotensin-converting enzyme 2 (ACE2) is the cellular receptor for the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that is engendering the severe coronavirus disease 2019 (COVID-19) pandemic. The spike (S) protein receptor-binding domain (RBD) of SARS-CoV-2 binds to the three sub-domains viz. amino acids (aa) 22-42, aa 79-84, and aa 330-393 of ACE2 on human cells to initiate entry. It was reported earlier that the receptor utilization capacity of ACE2 proteins from different sp
Document: Angiotensin-converting enzyme 2 (ACE2) is the cellular receptor for the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that is engendering the severe coronavirus disease 2019 (COVID-19) pandemic. The spike (S) protein receptor-binding domain (RBD) of SARS-CoV-2 binds to the three sub-domains viz. amino acids (aa) 22-42, aa 79-84, and aa 330-393 of ACE2 on human cells to initiate entry. It was reported earlier that the receptor utilization capacity of ACE2 proteins from different species, such as cats, chimpanzees, dogs, and cattle, are different. A comprehensive analysis of ACE2 receptors of nineteen species was carried out in this study, and the findings propose a possible SARS-CoV-2 transmission flow across these nineteen species.
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