Selected article for: "observed infection and susceptible population"
Author: Pagani, Gabriele; Giacomelli, Andrea; Conti, Federico; Bernacchia, Dario; Rondanin, Rossana; Prina, Andrea; Scolari, Vittore; Rizzo, Arianna; Beltrami, Martina; Caimi, Camilla; Gandolfi, Cecilia Eugenia; Castaldi, Silvana; Rivieccio, Bruno Alessandro; Buonanno, Giacomo; Marano, Giuseppe; Ottomano, Cosimo; Boracchi, Patrizia; Biganzoli, Elia; Galli, Massimo
Title: Prevalence of SARS-CoV-2 in an area of unrestricted viral circulation: Mass seroepidemiological screening in Castiglione d’Adda, Italy
  • Cord-id: k5xrwuyw
  • Document date: 2021_2_24
    • ID: k5xrwuyw
    Snippet: Castiglione D’Adda is one of the municipalities more precociously and severely affected by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) epidemic in Lombardy. With our study we aimed to understand the diffusion of the infection by mass serological screening. We searched for SARS-CoV-2 IgGs in the entire population on a voluntary basis using lateral flow immunochromatographic tests (RICT) on capillary blood (rapid tests). We then performed chemioluminescent serological assays
    Document: Castiglione D’Adda is one of the municipalities more precociously and severely affected by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) epidemic in Lombardy. With our study we aimed to understand the diffusion of the infection by mass serological screening. We searched for SARS-CoV-2 IgGs in the entire population on a voluntary basis using lateral flow immunochromatographic tests (RICT) on capillary blood (rapid tests). We then performed chemioluminescent serological assays (CLIA) and naso-pharyngeal swabs (NPS) in a randomized representative sample and in each subject with a positive rapid test. Factors associated with RICT IgG positivity were assessed by uni- and multivariate logistic regression models. Out of the 4143 participants, 918 (22·2%) showed RICT IgG positivity. In multivariable analysis, IgG positivity increases with age, with a significant non-linear effect (p = 0·0404). We found 22 positive NPSs out of the 1330 performed. Albeit relevant, the IgG prevalence is lower than expected and suggests that a large part of the population remains susceptible to the infection. The observed differences in prevalence might reflect a different infection susceptibility by age group. A limited persistence of active infections could be found after several weeks after the epidemic peak in the area.

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