Author: Linlin Zhang; Daizong Lin; Yuri Kusov; Yong Nian; Qingjun Ma; Jiang Wang; Albrecht von Brunn; Pieter Leyssen; Kristina Lanko; Johan Neyts; Adriaan de Wilde; Eric J. Snijder; Hong Liu; Rolf Hilgenfeld
Title: Alpha-ketoamides as broad-spectrum inhibitors of coronavirus and enterovirus replication Document date: 2020_2_10
ID: 7n8p9okf_49
Snippet: Regardless of which cell system is the most suitable one for the testing of peptidomimetic antiviral compounds, we next plan to test 11r in small-animal models for MERS and for Coxsackievirusinduced pancreatitis. In parallel, we aim to refine the experiments to quantify the accumulation of peptidomimetic protease inhibitors in different host-cell types, in the hope to find an explanation for the observed cell-type dependencies......
Document: Regardless of which cell system is the most suitable one for the testing of peptidomimetic antiviral compounds, we next plan to test 11r in small-animal models for MERS and for Coxsackievirusinduced pancreatitis. In parallel, we aim to refine the experiments to quantify the accumulation of peptidomimetic protease inhibitors in different host-cell types, in the hope to find an explanation for the observed cell-type dependencies.
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