Author: José L. Martínez; Francesca Arnoldi; Elisabeth M. Schraner; Catherine Eichwald; Daniela Silva-Ayala; Eunjoo Lee; Elizabeth Sztul; Óscar R. Burrone; Susana López; Carlos F. Arias
Title: The guanine nucleotide exchange factor GBF1 participates in rotavirus replication Document date: 2019_4_29
ID: jkjkkjrf_4
Snippet: These three GEFs activate Arf1, however GBF1 may also use Arf4 and Arf5 as substrates 113 (37) (38) (39) , while BIG1 and BIG2 can catalyze the activation of Arf3, Arf5 and Arf6 (40-42). In this study, we evaluated the role of the GBF1/COPI/Arf1 machinery in rotavirus 124 replication. We showed that the catalytic activity of GBF1 is critical for virus replication by 125 using two different pharmacological inhibitors, BFA and Golgicide A (GCA), an.....
Document: These three GEFs activate Arf1, however GBF1 may also use Arf4 and Arf5 as substrates 113 (37) (38) (39) , while BIG1 and BIG2 can catalyze the activation of Arf3, Arf5 and Arf6 (40-42). In this study, we evaluated the role of the GBF1/COPI/Arf1 machinery in rotavirus 124 replication. We showed that the catalytic activity of GBF1 is critical for virus replication by 125 using two different pharmacological inhibitors, BFA and Golgicide A (GCA), and knocking 126 down GBF1 expression by RNAi. We found that interfering with GBF1 activity significantly 127 All rights reserved. No reuse allowed without permission.
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