Selected article for: "column chromatography and petroleum ether"
Author: Linlin Zhang; Daizong Lin; Yuri Kusov; Yong Nian; Qingjun Ma; Jiang Wang; Albrecht von Brunn; Pieter Leyssen; Kristina Lanko; Johan Neyts; Adriaan de Wilde; Eric J. Snijder; Hong Liu; Rolf Hilgenfeld
Title: Alpha-ketoamides as broad-spectrum inhibitors of coronavirus and enterovirus replication
  • Document date: 2020_2_10
    • ID: 7n8p9okf_74
    Snippet: In a hydrogenation flask was placed compound 1 (4.0 g, 12.7 mmol), 5 mL of chloroform and 60 mL of methanol before the addition of PtO2. The resulting mixture was stirred under hydrogen at 20 o C for 12 h. Then the mixture was filtered over Celite to remove the catalyst. NaOAc (6.77 g, 25.5 mmol) was added to the filtrate before the resulting mixture was stirred at 60 o C for 12 h. The reaction was quenched with water (30 mL). The suspension was .....
    Document: In a hydrogenation flask was placed compound 1 (4.0 g, 12.7 mmol), 5 mL of chloroform and 60 mL of methanol before the addition of PtO2. The resulting mixture was stirred under hydrogen at 20 o C for 12 h. Then the mixture was filtered over Celite to remove the catalyst. NaOAc (6.77 g, 25.5 mmol) was added to the filtrate before the resulting mixture was stirred at 60 o C for 12 h. The reaction was quenched with water (30 mL). The suspension was extracted with ethyl acetate. The organic layers were combined, dried (MgSO4), and filtered. The light-brown filtrate was concentrated and purified by silica gel column chromatography (petroleum ether/ethyl acetate = 4/1) to give the product 2 (2.20 g, 61%) as white solid. 1 H NMR (CDCl3) δ 6.02 (1H, br), 5. Synthesis of (S)-methyl 2-amino-3-((S)-2-oxopyrrolidin-3yl)propanoate (3).

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