Selected article for: "protein expression and RNA expression"
Author: Jillian N Whelan; Joshua Hatterschide; David M. Renner; Beihua Dong; Robert H Silverman; Susan R Weiss
Title: The host antiviral ribonuclease L protein supports Zika virus replication factory formation to enhance infectious virus production
  • Document date: 2019_11_24
    • ID: f9mpkzni_10
    Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. . https://doi.org/10.1101/852194 doi: bioRxiv preprint dependent, and could not detect any RNase L activation by DENV using this assay 139 ( Figure 1B) . Despite reduced RNase L activation by DENV and KUNV, both viruses were 140 restricted by RNase L activity in WT cells ( Figure 1C) . Therefore, RNase L is not only 141 ineffective in inhibiting ZIKV infect.....
    Document: The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. . https://doi.org/10.1101/852194 doi: bioRxiv preprint dependent, and could not detect any RNase L activation by DENV using this assay 139 ( Figure 1B) . Despite reduced RNase L activation by DENV and KUNV, both viruses were 140 restricted by RNase L activity in WT cells ( Figure 1C) . Therefore, RNase L is not only 141 ineffective in inhibiting ZIKV infection, but also specifically promotes ZIKV production 142 ( Figure 1A, right panel) . 143 144 RNase L improves ZIKV RF function to increase ZIKV RNA and protein expression. 145

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