Author: Linlin Zhang; Daizong Lin; Yuri Kusov; Yong Nian; Qingjun Ma; Jiang Wang; Albrecht von Brunn; Pieter Leyssen; Kristina Lanko; Johan Neyts; Adriaan de Wilde; Eric J. Snijder; Hong Liu; Rolf Hilgenfeld
Title: Alpha-ketoamides as broad-spectrum inhibitors of coronavirus and enterovirus replication Document date: 2020_2_10
ID: 7n8p9okf_78
Snippet: (S)-methyl 2-cinnamamido-3-phenylpropanoate (4a). The methyl L-phenylalaninate hydrochloride (1.30 g, 6.0 mmol) was dissolved in 20 mL CH2Cl2, and then cinnamoyl chloride (1.00 g, 6.0 mmol), triethylamine (1.69 mL, 12.0 mmol) were added, before the reaction was stirred for 2 h at room temperature. The reaction mixture was diluted with 20 mL CH2Cl2, washed with 50 mL of saturated brine (2×25 mL), and dried over Na2SO4. The solvent was evaporated .....
Document: (S)-methyl 2-cinnamamido-3-phenylpropanoate (4a). The methyl L-phenylalaninate hydrochloride (1.30 g, 6.0 mmol) was dissolved in 20 mL CH2Cl2, and then cinnamoyl chloride (1.00 g, 6.0 mmol), triethylamine (1.69 mL, 12.0 mmol) were added, before the reaction was stirred for 2 h at room temperature. The reaction mixture was diluted with 20 mL CH2Cl2, washed with 50 mL of saturated brine (2×25 mL), and dried over Na2SO4. The solvent was evaporated and the product 4a was obtained as white solid (1.75 g, 95%), which could be used for the next step without further purification.
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