Author: Ng, Dianna L.; Al Hosani, Farida; Keating, M. Kelly; Gerber, Susan I.; Jones, Tara L.; Metcalfe, Maureen G.; Tong, Suxiang; Tao, Ying; Alami, Negar N.; Haynes, Lia M.; Mutei, Mowafaq Ali; Abdel-Wareth, Laila; Uyeki, Timothy M.; Swerdlow, David L.; Barakat, Maha; Zaki, Sherif R.
Title: Clinicopathologic, Immunohistochemical, and Ultrastructural Findings of a Fatal Case of Middle East Respiratory Syndrome Coronavirus Infection in the United Arab Emirates, April 2014 Cord-id: lh8czr0a Document date: 2016_2_5
ID: lh8czr0a
Snippet: Middle East respiratory syndrome coronavirus (MERS-CoV) infection causes an acute respiratory illness and is associated with a high case fatality rate; however, the pathogenesis of severe and fatal MERS-CoV infection is unknown. We describe the histopathologic, immunohistochemical, and ultrastructural findings from the first autopsy performed on a fatal case of MERS-CoV in the world, which was related to a hospital outbreak in the United Arab Emirates in April 2014. The main histopathologic find
Document: Middle East respiratory syndrome coronavirus (MERS-CoV) infection causes an acute respiratory illness and is associated with a high case fatality rate; however, the pathogenesis of severe and fatal MERS-CoV infection is unknown. We describe the histopathologic, immunohistochemical, and ultrastructural findings from the first autopsy performed on a fatal case of MERS-CoV in the world, which was related to a hospital outbreak in the United Arab Emirates in April 2014. The main histopathologic finding in the lungs was diffuse alveolar damage. Evidence of chronic disease, including severe peripheral vascular disease, patchy cardiac fibrosis, and hepatic steatosis, was noted in the other organs. Double staining immunoassays that used anti–MERS-CoV antibodies paired with immunohistochemistry for cytokeratin and surfactant identified pneumocytes and epithelial syncytial cells as important targets of MERS-CoV antigen; double immunostaining with dipeptidyl peptidase 4 showed colocalization in scattered pneumocytes and syncytial cells. No evidence of extrapulmonary MERS-CoV antigens were detected, including the kidney. These results provide critical insights into the pathogenesis of MERS-CoV in humans.
Search related documents:
Co phrase search for related documents- abdominal effusion and acute renal failure: 1
- abdominal effusion and acute respiratory syndrome: 1, 2, 3
- abdominal effusion and admission day: 1
- abdominal effusion and liver identify: 1
- accession number and acute renal failure: 1
- accession number and acute respiratory syndrome: 1, 2, 3
- acute bronchitis and low respiratory: 1, 2, 3
- acute kidney injury and admission day: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- acute kidney injury and low respiratory: 1, 2, 3, 4
- acute renal failure and admission day: 1, 2, 3, 4, 5, 6
- acute renal failure and low respiratory: 1
- acute respiratory illness and admission day: 1, 2, 3, 4, 5
- acute respiratory illness and low respiratory: 1, 2, 3, 4, 5, 6, 7, 8
- acute respiratory illness and low respiratory tract: 1, 2
- acute respiratory syndrome and admission day: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- acute respiratory syndrome and liver identify: 1, 2, 3, 4, 5
- acute respiratory syndrome and low dose oral prednisolone: 1
- acute respiratory syndrome and low respiratory: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- acute respiratory syndrome and low respiratory tract: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
Co phrase search for related documents, hyperlinks ordered by date