Selected article for: "assembly virus particle and viral particle"
Author: José L. Martínez; Francesca Arnoldi; Elisabeth M. Schraner; Catherine Eichwald; Daniela Silva-Ayala; Eunjoo Lee; Elizabeth Sztul; Óscar R. Burrone; Susana López; Carlos F. Arias
Title: The guanine nucleotide exchange factor GBF1 participates in rotavirus replication
  • Document date: 2019_4_29
    • ID: jkjkkjrf_27
    Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. (71) and classical swine fever virus (72) , COPI/Arf1 has been shown to be necessary for 354 genome replication as well as for viral protein expression. COPI/Arf1 has also been shown 355 to be critical for viral particle assembly of influenza and the Chandipura virus .....
    Document: The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. (71) and classical swine fever virus (72) , COPI/Arf1 has been shown to be necessary for 354 genome replication as well as for viral protein expression. COPI/Arf1 has also been shown 355 to be critical for viral particle assembly of influenza and the Chandipura virus (62, 73) . The 356 specific mechanism through which COPI/Arf1 participate in these processes has not been 357 characterized; however, GBF1, involved in the first step of the COPI/Arf1 transport process, 358 has been shown to play an important role for the replication of some of these viruses. For In this work, we studied the effect of inhibiting the function of the GBF1/COPI/Arf1 364 machinery on the replication of rotavirus using the pharmacological inhibitors BFA and 365 GCA. We found that both inhibitors induced a significant reduction in the progeny 366 production of different rotavirus strains belonging to different G and P serotypes, indicating 367 that these drugs block a common pathway for all these viruses. The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. . https://doi.org/10.1101/619924 doi: bioRxiv preprint

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