Author: Ballesteros-Briones, MarÃa Cristina; Silva-Pilipich, Noelia; Herrador-Cañete, Guillermo; Vanrell, Lucia; Smerdou, Cristian
Title: A new generation of vaccines based on alphavirus self-amplifying RNA Cord-id: msuluuuu Document date: 2020_9_6
ID: msuluuuu
Snippet: DNA or mRNA vaccines have potential advantages over conventional vaccines since they are easier to manufacture and have higher safety profiles. In particular, self-amplifying RNA (saRNA) derived from alphavirus expression vectors has shown to be very efficient to induce humoral and cellular responses against many antigens in preclinical models, being superior to non-replicating mRNA and DNA. This is mainly due to the fact that saRNA can provide very high expression levels and simultaneously indu
Document: DNA or mRNA vaccines have potential advantages over conventional vaccines since they are easier to manufacture and have higher safety profiles. In particular, self-amplifying RNA (saRNA) derived from alphavirus expression vectors has shown to be very efficient to induce humoral and cellular responses against many antigens in preclinical models, being superior to non-replicating mRNA and DNA. This is mainly due to the fact that saRNA can provide very high expression levels and simultaneously induces strong innate responses, potentiating immunity. saRNA can be administered as viral particles or DNA, but direct delivery as RNA represents a safer and more simple approach. Although saRNA can be delivered as naked RNA, in vivo transfection can be enhanced by electroporation or by complexing it with cationic lipids or polymers. Alphavirus saRNA could have broad application to vaccinate against human pathogens, including emerging ones like SARS-CoV-2, for which clinical trials have been recently initiated.
Search related documents:
Co phrase search for related documents- acid vaccine and lnp system: 1
- adjuvant formulation and low immunogenicity: 1
Co phrase search for related documents, hyperlinks ordered by date