Author: Gonçalves, Antonio; Bertrand, Julie; Ke, Ruian; Comets, Emmanuelle; de Lamballerie, Xavier; Malvy, Denis; Pizzorno, Andrés; Terrier, Olivier; Calatrava, Manuel Rosa; Mentré, France; Smith, Patrick; Perelson, Alan S; Guedj, Jérémie
Title: Timing of antiviral treatment initiation is critical to reduce SARS-Cov-2 viral load Cord-id: n6l2804j Document date: 2020_4_7
ID: n6l2804j
Snippet: We modeled the viral dynamics of 13 untreated patients infected with SARS-CoV-2 to infer viral growth parameters and predict the effects of antiviral treatments. In order to reduce peak viral load by more than 2 logs, drug efficacy needs to be greater than 80% if treatment is administered after symptom onset; an efficacy of 50% could be sufficient if treatment is initiated before symptom onset. Given their pharmacokinetic/pharmacodynamic properties, current investigated drugs may be in a range o
Document: We modeled the viral dynamics of 13 untreated patients infected with SARS-CoV-2 to infer viral growth parameters and predict the effects of antiviral treatments. In order to reduce peak viral load by more than 2 logs, drug efficacy needs to be greater than 80% if treatment is administered after symptom onset; an efficacy of 50% could be sufficient if treatment is initiated before symptom onset. Given their pharmacokinetic/pharmacodynamic properties, current investigated drugs may be in a range of 20-70% efficacy. They may help control virus if administered very early, but may not have a major effect in severe patients.
Search related documents:
Co phrase search for related documents, hyperlinks ordered by date