Selected article for: "IMPDH enzyme and monophosphate dehydrogenase IMPDH enzyme"
Author: Natalya Bukreyeva; Emily K. Mantlo; Rachel A. Sattler; Cheng Huang; Slobodan Paessler; Jerry Zeldis
Title: The IMPDH inhibitor merimepodib suppresses SARS-CoV-2 replication in vitro
  • Document date: 2020_4_9
    • ID: geb4esu5_2
    Snippet: The effect is dose-dependent, and concentrations as low as 3.3 μM significantly reduced viral titers when the cells were pretreated prior to infection. The results of this study provide evidence that MMPD may be a viable treatment option for COVID-19. Drugs with history of being tested in human patients or used for treatment of other conditions offer the most expedient option, and several such drugs are currently being tested for efficacy agains.....
    Document: The effect is dose-dependent, and concentrations as low as 3.3 μM significantly reduced viral titers when the cells were pretreated prior to infection. The results of this study provide evidence that MMPD may be a viable treatment option for COVID-19. Drugs with history of being tested in human patients or used for treatment of other conditions offer the most expedient option, and several such drugs are currently being tested for efficacy against SARS-CoV-2, including many broad-spectrum antivirals. One such antiviral, merimepodib (MMPD), has already being tested against hepatitis C in patients as well as against many emerging RNA viruses in cell culture, including Zika, Ebola, Lassa, Junin, and . CC-BY-NC-ND 4.0 International license author/funder. It is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.07.028589 doi: bioRxiv preprint chikungunya viruses (1) . MMPD noncompetitively inhibits inosine-5'-monophosphate dehydrogenase (IMPDH), an enzyme responsible for de novo synthesis of guanosine nucleotides (2, 3) . In vitro, inhibition can be reversed by addition of exogenous guanosine (4).

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