Author: Naslavsky, Michel Satya; Vidigal, Mateus; Matos, Larissa do Rêgo Barros; Cória, Vivian Romanholi; Batista, Pedro Benedito; Razuk, Ãlvaro; Saldiva, Paulo Hilário Nascimento; Dolhnikoff, Marisa; Schidlowski, Laire; Prando, Carolina; Cunha-Neto, Edécio; Condino-Neto, Antonio; Passos-Bueno, Maria Rita; Zatz, Mayana
Title: Extreme phenotypes approach to investigate host genetics and COVID-19 outcomes Cord-id: o3gc8j1a Document date: 2021_3_1
ID: o3gc8j1a
Snippet: COVID-19 comprises clinical outcomes of SARS-CoV-2 infection and is highly heterogeneous, ranging from asymptomatic individuals to deceased young adults without comorbidities. There is growing evidence that host genetics play an important role in COVID-19 severity, including inborn errors of immunity, age-related inflammation and immunosenescence. Here we present a brief review on the known order of events from infection to severe system-wide disturbance due to COVID-19 and summarize potential c
Document: COVID-19 comprises clinical outcomes of SARS-CoV-2 infection and is highly heterogeneous, ranging from asymptomatic individuals to deceased young adults without comorbidities. There is growing evidence that host genetics play an important role in COVID-19 severity, including inborn errors of immunity, age-related inflammation and immunosenescence. Here we present a brief review on the known order of events from infection to severe system-wide disturbance due to COVID-19 and summarize potential candidate genes and pathways. Finally, we propose a strategy of subject’s ascertainment based on phenotypic extremes to take part in genomic studies and elucidate intrinsic risk factors involved in COVID-19 severe outcomes.
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