Selected article for: "human monocyte and macrophage monocyte"
Author: Minfeng Liao; Yang Liu; Jin Yuan; Yanling Wen; Gang Xu; Juanjuan Zhao; Lin Chen; Jinxiu Li; Xin Wang; Fuxiang Wang; Lei Liu; Shuye Zhang; Zheng Zhang
Title: The landscape of lung bronchoalveolar immune cells in COVID-19 revealed by single-cell RNA sequencing
  • Document date: 2020_2_26
    • ID: 8l1vfsbc_15
    Snippet: The increased lung macrophage population was present in severe COVID-19 patients. To further understand the macrophage heterogeneity, we re-clustered the macrophages and showed 22 clusters (Figure 2A ). Recent studies have identified three distinct human lung macrophage subsets by FCN1 (monocyte derived), SPP1 (pro-fibrotic) and FABP4 (alveolar macrophage, AM) marker expression [13] . Referring to the classification criteria and other macrophage .....
    Document: The increased lung macrophage population was present in severe COVID-19 patients. To further understand the macrophage heterogeneity, we re-clustered the macrophages and showed 22 clusters (Figure 2A ). Recent studies have identified three distinct human lung macrophage subsets by FCN1 (monocyte derived), SPP1 (pro-fibrotic) and FABP4 (alveolar macrophage, AM) marker expression [13] . Referring to the classification criteria and other macrophage markers ( Figure S3A ), we found that most macrophage clusters (except for C15 as a dendritic cell subset) in our study could also be grouped by FCN1, SPP1 and FABP4 expression patterns. Group 1 includes C9 and C10 (FCN1 hi only), Group 2 includes C0, C6, C12, C16 and C19 (FCN1 lo SPP1 + ), Group 3 includes C7, C8 and C18 (FCN1 -SPP1 + ), Group 4 contains C1, C2, C3, C4, C5, C11, C13, C14, C17, C20, C21, C22 (FABP4 + ) ( Figure 2B ).

    Search related documents:
    Co phrase search for related documents
    • alveolar macrophage and lung macrophage: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14
    • alveolar macrophage and macrophage marker: 1, 2, 3
    • alveolar macrophage and macrophage subset: 1, 2
    • alveolar macrophage and marker expression: 1, 2, 3, 4
    • alveolar macrophage and severe patient: 1
    • cell subset and dendritic cell subset: 1, 2, 3
    • cell subset and human lung: 1, 2, 3, 4, 5, 6
    • cell subset and marker expression: 1
    • cell subset and recent study: 1
    • expression pattern and human lung: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
    • expression pattern and lung macrophage: 1, 2
    • expression pattern and marker expression: 1, 2, 3, 4, 5, 6, 7
    • expression pattern and recent study: 1, 2, 3, 4
    • human lung and lung macrophage: 1, 2, 3, 4, 5, 6, 7, 8, 9
    • human lung and macrophage marker: 1
    • human lung and marker expression: 1, 2, 3
    • human lung and recent study: 1, 2, 3
    • human lung and severe patient: 1, 2
    • lung macrophage and macrophage cluster: 1