Author: Lyudmila Kovalchuke; Eugene V. Mosharov; Oren A. Levy; Lloyd A. Greene
Title: Stress-induced phospho-ubiquitin formation causes parkin degradation Document date: 2018_12_5
ID: ceepyyxj_3
Snippet: Additionally, mitochondrial depolarization has also been shown to cause parkin loss. This loss is generally thought to be linked to the process of parkin-mediated mitophagy [36] [37] [38] [39] , though one study has suggested that parkin's autoubiquitination leads to its degradation and prevents mitophagy following mitochondrial depolarization [40] . The degree to which parkin loss from mitochondrial depolarization aligns mechanistically with par.....
Document: Additionally, mitochondrial depolarization has also been shown to cause parkin loss. This loss is generally thought to be linked to the process of parkin-mediated mitophagy [36] [37] [38] [39] , though one study has suggested that parkin's autoubiquitination leads to its degradation and prevents mitophagy following mitochondrial depolarization [40] . The degree to which parkin loss from mitochondrial depolarization aligns mechanistically with parkin loss from other stressors is uncertain. One possible contributor in common is the mitochondrial kinase PINK1, that parkin's association with phospho-Ub generated by other stressors also leads to parkin degradation, suggesting that this mechanism is broadly-generalizable. Surprisingly, we find that parkin loss downstream of its association with phospho-Ub does not appear to require canonical mitochondrial parkin activity or mitophagy.
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