Epidemiology and Clinical Presentation of Children Hospitalized with SARS-CoV-2 Infection in Suburbs of Paris

Gaborieau, Louise; Delestrain, Celine; Bensaid, Philippe; Vizeneux, Audrey; Blanc, Philippe; Garraffo, Aurélie; Georget, Emilie; Chalvon, Arnaud; Garrec, Nathalie; Laoudi, Yacine; Varon, Emmanuelle; Rouget, Sébastien; Pupin, Alexandre; Abdel Aal, Khaled; Toulorge, David; Ducrocq, Sarah; Barrey, Catherine; Pantalone, Letitia; Robert, Blandine; Joly-Sanchez, Lydie; Thach, Caroline; Masserot-Lureau, Caroline; Chahine, Jamilé; Risso Garcia-Roudaut, Veronica; Rozental, Jonathan; Nathanson, Sylvie; Khaled, Mohamed; Mandelcwajg, Alexis; Demayer, Nadia; Muller, Stéphanie; Mazerghane, Mustapha; Epaud, Ralph; Pellegrino, Béatrice; Madhi, Fouad

Understanding the clinical presentation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and prognosis in children is a major issue. Children often present mild symptoms, and some severe forms require paediatric intensive care, with in some cases a fatal prognosis. Our aim was to identify the epidemiological characteristics, clinical presentation, and prognosis of children with coronavirus disease 2019 (Covid-19) hospitalized in Paris suburb hospitals. In this prospective, observational, multicentre study, we included children hospitalized in paediatric departments of Paris suburb hospitals from 23 March 2020 to 10 May 2020, during the national lockdown in France with confirmed SARS-CoV-2 infection (positive RNA test on a nasopharyngeal swab) or highly suspected infection (clinical, biological, and/or radiological data features suggestive for SARS-CoV-2 infection). A total of 192 children were included for confirmed (n = 157) or highly suspected (n = 35) SARS-CoV-2 infection. The median age was one year old (interquartile range 0.125–11) with a sex ratio 1.3:1. Fever was recorded in 147 (76.6%) children and considered poorly tolerated in 29 (15.1%). The symptoms ranged from rhinorrhoea (34.4%) and gastrointestinal (35.5%) to respiratory distress (25%). Only 10 (5.2%) children had anosmia and five (2.6%) had chest pain. An underlying condition was identified in almost 30% of the children in our study. Overall, 24 (12.5%) children were admitted to paediatric intensive care units, 12 required mechanical ventilation, and three died. For children in Paris suburbs, most cases of Covid-19 showed mild or moderate clinical expression. However, one-eighth of children were admitted to paediatric intensive care units and three died.