Selected article for: "accessory cell and acute respiratory syndrome"
Author: Uddin, Md. Hafiz; Zonder, Jeffrey A.; Azmi, Asfar S.
Title: Exportin 1 inhibition as antiviral therapy
  • Cord-id: oy5921pq
  • Document date: 2020_6_20
    • ID: oy5921pq
    Snippet: Coronavirus 2019 (COVID-19; caused by Severe Acute Respiratory Syndrome Coronavirus 2; SARS-CoV-2) is a currently global health problem. Previous studies showed that blocking nucleocytoplasmic transport with exportin 1 (XPO1) inhibitors originally developed as anticancer drugs can quarantine key viral accessory proteins and genomic materials in the nucleus of host cell and reduce virus replication and immunopathogenicity. These observations support the concept of the inhibition of nuclear export
    Document: Coronavirus 2019 (COVID-19; caused by Severe Acute Respiratory Syndrome Coronavirus 2; SARS-CoV-2) is a currently global health problem. Previous studies showed that blocking nucleocytoplasmic transport with exportin 1 (XPO1) inhibitors originally developed as anticancer drugs can quarantine key viral accessory proteins and genomic materials in the nucleus of host cell and reduce virus replication and immunopathogenicity. These observations support the concept of the inhibition of nuclear export as an effective strategy against an array of viruses, including influenza A, B, and SARS-CoV. Clinical studies using the XPO1 inhibitor selinexor as a therapy for COVID-19 infection are in progress.

    Search related documents:
    Co phrase search for related documents
    • absence presence and activator signal transducer: 1
    • absence presence and acute ards respiratory distress syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
    • absence presence and acute ards respiratory distress syndrome development: 1
    • absence presence and acute respiratory: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • absence presence and lung pathology: 1
    • accessory protein and activator signal transducer: 1, 2, 3
    • accessory protein and acute ards respiratory distress syndrome: 1
    • accessory protein and acute respiratory: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • accessory protein and lung pathology: 1, 2
    • accumulation result and acute ards respiratory distress syndrome: 1
    • accumulation result and acute respiratory: 1, 2, 3, 4
    • accumulation result and adaptor protein: 1
    • acid export and acute respiratory: 1
    • activate caspase and acute respiratory: 1, 2
    • activator signal transducer and acute ards respiratory distress syndrome: 1, 2, 3, 4, 5
    • activator signal transducer and acute respiratory: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • acute ards respiratory distress syndrome and adaptor protein: 1
    • acute respiratory and localization retention: 1, 2, 3
    • acute respiratory and localization retention signal: 1