Selected article for: "interaction network and protein interaction network"
Author: Lea Gaucherand; Brittany K. Porter; Summer K. Schmaling; Christopher Harley Rycroft; Yuzo Kevorkian; Craig McCormick; Denys A. Khaperskyy; Marta Maria Gaglia
Title: The influenza A virus endoribonuclease PA-X usurps host mRNA processing machinery to limit host gene expression
  • Document date: 2018_10_14
    • ID: 8k7w467p_14
    Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. . https://doi.org/10.1101/442996 doi: bioRxiv preprint (nucleolin, nucleophosmin) that were enriched >2-fold compared to controls across all three 314 runs. Because nucleolin and nucleophosmin are abundant proteins that move in and out of 315 nucleoli, these interactions may explain the apparent nucleolar accumulation of biotinylated 316 proteins ( Figures .....
    Document: The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. . https://doi.org/10.1101/442996 doi: bioRxiv preprint (nucleolin, nucleophosmin) that were enriched >2-fold compared to controls across all three 314 runs. Because nucleolin and nucleophosmin are abundant proteins that move in and out of 315 nucleoli, these interactions may explain the apparent nucleolar accumulation of biotinylated 316 proteins ( Figures S5A, S5C) . STRING protein-protein interaction network analysis of the hits 317 revealed several physical and functional interaction nodes, including protein trafficking, 318 transcription/translation and mRNA processing ( Figure 6D ). Similarly, GO term analysis 319 revealed a strong association with mRNA processing, RNA splicing and mRNA metabolic 320 process functions among the high-confidence hits ( Figure 6E ). In particular, several proteins 321 associated with mRNA splicing (RBM39, PUF60, PRPF4) and/or polyadenylation (NUDT21/ 322 CPSF5, CPSF6) were identified as X-ORF-interacting proteins. These data show that the PA-X 323 C-terminal X-ORF is physically recruited to protein complexes involved in nuclear mRNA 324 processing, which likely explains its preferential degradation of RNAs that have undergone 325 co/post-transcriptional processing. 326

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