Selected article for: "chronic rhinitis and CRS chronic rhinosinusitis"
Author: Ryan M. Carey; Jenna R. Freund; Benjamin M. Hariri; Nithin D. Adappa; James N. Palmer; Robert J. Lee
Title: Altered polarization of PAR-2 signaling during airway epithelial remodeling
  • Document date: 2020_1_9
    • ID: 8iet67u3_1
    Snippet: Protease-activated receptors (PARs) are G protein-coupled receptors (GPCRs) that can drive inflammation in asthma, chronic rhinosinusitis (CRS), and allergic rhinitis. 1, 2 PARs are activated by proteolytic cleavage of the extracellular N-terminus, exposing an intramolecular tethered ligand. 1, 2 PAR-2 may be activated by mast cell tryptase, 3 neutrophil elastase, 4 Alternaria fungal proteases, 5 and house dust mite proteases 6 and may promote Th.....
    Document: Protease-activated receptors (PARs) are G protein-coupled receptors (GPCRs) that can drive inflammation in asthma, chronic rhinosinusitis (CRS), and allergic rhinitis. 1, 2 PARs are activated by proteolytic cleavage of the extracellular N-terminus, exposing an intramolecular tethered ligand. 1, 2 PAR-2 may be activated by mast cell tryptase, 3 neutrophil elastase, 4 Alternaria fungal proteases, 5 and house dust mite proteases 6 and may promote Th2 inflammation in bronchial epithelial cells. 7 We previously found that PAR-2 is expressed on the basolateral membrane of healthy well-polarized differentiated primary sinonasal epithelial ciliated cells, where it elevates intracellular calcium to increase ciliary beating and apical membrane Clsecreation, 8 suggesting PAR-2 promotes epithelial mucociliary clearance in response to protease activity.

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