Author: Courtney Mycroft-West; Dunhao Su; Stefano Elli; Scott Guimond; Gavin Miller; Jeremy Turnbull; Edwin Yates; Marco Guerrini; David Fernig; Marcelo Lima; Mark Skidmore
Title: The 2019 coronavirus (SARS-CoV-2) surface protein (Spike) S1 Receptor Binding Domain undergoes conformational change upon heparin binding Document date: 2020_3_2
ID: 0d77ojnb_1
Snippet: Heparin, the second most widely used drug by weight globally, is formulated as a polydisperse, heterogenous natural product. Unfractionated heparin, low molecular weight heparins and heparinoids are clinically approved as anticoagulants / thrombotic with excellent safety, stability, bioavailability and pharmacokinetic profiles. Crucially, heparin and its derivatives, some of which lacking significant anticoagulant activity 1 , are an under-exploi.....
Document: Heparin, the second most widely used drug by weight globally, is formulated as a polydisperse, heterogenous natural product. Unfractionated heparin, low molecular weight heparins and heparinoids are clinically approved as anticoagulants / thrombotic with excellent safety, stability, bioavailability and pharmacokinetic profiles. Crucially, heparin and its derivatives, some of which lacking significant anticoagulant activity 1 , are an under-exploited antiviral drug class, despite possessing broad-spectrum activity against a multitude of distinct viruses, including coronaviridae and SARSassociated coronavirus strain HSR1 2 , in addition to flaviviruses 3, 4 , herpes 5 , influenza 6 and HIV 7, 8 .
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