Author: Ryan M. Carey; Jenna R. Freund; Benjamin M. Hariri; Nithin D. Adappa; James N. Palmer; Robert J. Lee
Title: Altered polarization of PAR-2 signaling during airway epithelial remodeling Document date: 2020_1_9
ID: 8iet67u3_18
Snippet: We thus chose the 4-day exposure time to IL-13 or submersion (21 days of differentiation plus further 4 days of IL-13 or submersion, here termed Day 21 + 4) for further experiments as it was a timepoint where the epithelium was remodeled but barrier function remained intact. At this time point, we saw no differences in expression of PAR-2 by qPCR (Supplementary Fig S9C) , which mimicked a lack of differences observed in nasal polyp tissue (freque.....
Document: We thus chose the 4-day exposure time to IL-13 or submersion (21 days of differentiation plus further 4 days of IL-13 or submersion, here termed Day 21 + 4) for further experiments as it was a timepoint where the epithelium was remodeled but barrier function remained intact. At this time point, we saw no differences in expression of PAR-2 by qPCR (Supplementary Fig S9C) , which mimicked a lack of differences observed in nasal polyp tissue (frequently characterized by type II inflammation) and control middle turbinate tissue (Supplementary Fig S9C) , in contrast to another study. 48 As a control, we did see increased expression of PAR-2 in ALIs after lipopolysaccharide (LPS), agreeing with previous results from bronchial fibroblasts (Supplementary Fig S9C) . 49
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