Author: Minfeng Liao; Yang Liu; Jin Yuan; Yanling Wen; Gang Xu; Juanjuan Zhao; Lin Chen; Jinxiu Li; Xin Wang; Fuxiang Wang; Lei Liu; Shuye Zhang; Zheng Zhang
Title: The landscape of lung bronchoalveolar immune cells in COVID-19 revealed by single-cell RNA sequencing Document date: 2020_2_26
ID: 8l1vfsbc_36
Snippet: However, the roles of T cells, especially resident T cells, in controlling the disease severity of SARS-CoV infected patients are not proved yet. Here, we applied both scRNA-seq and TCR-seq to characterize the lung resident T cell populations. Our data not only revealed the presence of a larger population of CD8 + T effectors in mild group, but also showed that these CD8 + T cells contain highly expanded clones, indicating their SARS-CoV-2 specif.....
Document: However, the roles of T cells, especially resident T cells, in controlling the disease severity of SARS-CoV infected patients are not proved yet. Here, we applied both scRNA-seq and TCR-seq to characterize the lung resident T cell populations. Our data not only revealed the presence of a larger population of CD8 + T effectors in mild group, but also showed that these CD8 + T cells contain highly expanded clones, indicating their SARS-CoV-2 specificity. Thus, we presented the fresh evidence that CD8 + T cell response likely holds the key for successful viral control in COVID-19 patients. This data will guide the future development of vaccine and potential T-cell immunotherapy for the severe viral respiratory infections.
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