Author: Van Praet, Jens T; Vandecasteele, Stefaan; De Roo, Anneleen; Vynck, Matthijs; De Vriese, An S; Reynders, Marijke
Title: Dynamics of the cellular and humoral immune response after BNT162b2 mRNA Covid-19 vaccination in Covid-19 naive nursing home residents. Cord-id: qd6oejqm Document date: 2021_9_13
ID: qd6oejqm
Snippet: Short-term humoral and cellular immune responses are diminished after BNT162b2 mRNA Covid-19 vaccination in Covid-19 naive nursing home residents, a population particularly vulnerable to the disease. We found both responses to decline after four weeks and remain lower than those of healthcare workers after twenty-four weeks, with an estimated half-life of the antibody response of 47 days. At four weeks, older age was significantly associated with a decreased humoral response, and diabetes mellit
Document: Short-term humoral and cellular immune responses are diminished after BNT162b2 mRNA Covid-19 vaccination in Covid-19 naive nursing home residents, a population particularly vulnerable to the disease. We found both responses to decline after four weeks and remain lower than those of healthcare workers after twenty-four weeks, with an estimated half-life of the antibody response of 47 days. At four weeks, older age was significantly associated with a decreased humoral response, and diabetes mellitus and active malignancy with a decreased cellular response. Our results imply that Covid-19 naive nursing home residents are a target group for booster vaccination trials.
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