Author: Renhong Yan; Yuanyuan Zhang; Yingying Guo; Lu Xia; Qiang Zhou
Title: Structural basis for the recognition of the 2019-nCoV by human ACE2 Document date: 2020_2_20
ID: elo7kfun_6
Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.02.19.956946 doi: bioRxiv preprint we will refer it as RBD for short if not specified) from Sino Biological Inc., mixed it with our purified ACE2-B 0 AT1 complex at a stoichiometric ratio of ~ 1.1 to 1, and proceeded with cryo-grid preparation and imaging. Following the same protocol for data processing as for the ACE2-B 0 AT1 complex, a 3D .....
Document: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.02.19.956946 doi: bioRxiv preprint we will refer it as RBD for short if not specified) from Sino Biological Inc., mixed it with our purified ACE2-B 0 AT1 complex at a stoichiometric ratio of ~ 1.1 to 1, and proceeded with cryo-grid preparation and imaging. Following the same protocol for data processing as for the ACE2-B 0 AT1 complex, a 3D EM reconstruction of the ternary complex was obtained. The structural findings about the dimeric full-length ACE2 and its complex interaction with B 0 AT1, which were reported in detail in our bioRxiv posting (1) , will not be repeated here. In this manuscript, we will focus on the interface between ACE2 and RBD.
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