Selected article for: "absolute effect and low quality"
Author: Primiano Iannone; Greta Castellini; Daniela Coclite; Antonello Napoletano; Alice Fauci; Laura Iacorossi; Daniela D'Angelo; Cristina Renzi; Giuseppe La Torre; Claudio Mastroianni; Silvia Gianola
Title: The need of health policy perspective to protect Healthcare Workers during COVID-19 pandemic. A GRADE rapid review on the N95 respirators effectiveness.
  • Document date: 2020_4_11
    • ID: 1q8tqeg7_39
    Snippet: No RCTs addressing the prevention of SARS-CoV-2 infection among HCWs was found. For CRI, we included two cluster RCTs with 2594 HCWs from in-patient hospital setting [30, 31] . Adjusting data for clustering, using N95 respirators reduced meaningfully the risk of developing CRI respect to surgical masks (2 RCTs, RR 0.43, 95% CI 0.29, 0.64; I 2 =0%) (Fig 1) , with low quality of evidence and an absolute effect of preventing 73 more (95% CI from 91 .....
    Document: No RCTs addressing the prevention of SARS-CoV-2 infection among HCWs was found. For CRI, we included two cluster RCTs with 2594 HCWs from in-patient hospital setting [30, 31] . Adjusting data for clustering, using N95 respirators reduced meaningfully the risk of developing CRI respect to surgical masks (2 RCTs, RR 0.43, 95% CI 0.29, 0.64; I 2 =0%) (Fig 1) , with low quality of evidence and an absolute effect of preventing 73 more (95% CI from 91 more to 46 more) infections per 1000 HCWs wearing N95 respirators (Table 2 ). According to the Claxton model [26] , in the worst case scenario the added benefit of more research in reducing uncertainty would be of reducing to 51 infections (upper 90% CI limit) prevented per 1000

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