Selected article for: "design study concept and study concept"
Author: Brian G. Pierce; Zhen-Yong Keck; Ruixue Wang; Patrick Lau; Kyle Garagusi; Khadija Elkholy; Eric A. Toth; Richard A. Urbanowicz; Johnathan D. Guest; Pragati Agnihotri; Melissa C. Kerzic; Alexander Marin; Alexander K. Andrianov; Jonathan K. Ball; Roy A. Mariuzza; Thomas R. Fuerst; Steven K.H. Foung
Title: Structure-based design of hepatitis C virus E2 glycoprotein improves serum binding and cross-neutralization
  • Document date: 2020_4_17
    • ID: b6to1v4u_41
    Snippet: This study provides a proof-of-concept for computational structure-based design of the HCV E2 glycoprotein to modulate its antigenicity and immunogenicity. Future studies with the H445P design include testing of its antigenicity and immunogenicity in the context of HCV E1E2, testing immunogenicity in other animal models, as well as confirmation of its impact on E2 structure through high resolution X-ray structural characterization and additional .....
    Document: This study provides a proof-of-concept for computational structure-based design of the HCV E2 glycoprotein to modulate its antigenicity and immunogenicity. Future studies with the H445P design include testing of its antigenicity and immunogenicity in the context of HCV E1E2, testing immunogenicity in other animal models, as well as confirmation of its impact on E2 structure through high resolution X-ray structural characterization and additional biophysical characterization. Furthermore, additional designed proline substitutions in this flexible E2

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