Selected article for: "cell activation and directly activate"
Author: yongwen chen; Zeqing Feng; Bo Diao; Rongshuai Wang; Gang Wang; Chenhui Wang; Yingjun Tan; Liang Liu; Changsong Wang; Ying Liu; Yueping Liu; Zilin Yuan; Liang Ren; Yuzhang Wu
Title: The Novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Directly Decimates Human Spleens and Lymph Nodes
  • Document date: 2020_3_31
    • ID: dvpqkmnh_25
    Snippet: Because SARS-CoV-2 virus does not infect lymphocyte directly, we think the persistence of viral antigen could constitutively activate T cells and B cells in spleen and LNs, thus causing activation-induced cell death (AICD), which is mediated by Fas/FasL signaling. [17] [18] [19] Immunohistochemistry showed that spleen and LN tissues from autopsies and normal healthy controls manifested similar levels of FasL expression (Figure 4C) . On the other .....
    Document: Because SARS-CoV-2 virus does not infect lymphocyte directly, we think the persistence of viral antigen could constitutively activate T cells and B cells in spleen and LNs, thus causing activation-induced cell death (AICD), which is mediated by Fas/FasL signaling. [17] [18] [19] Immunohistochemistry showed that spleen and LN tissues from autopsies and normal healthy controls manifested similar levels of FasL expression (Figure 4C) . On the other hand, the expression of Fas was significantly upregulated in virus infected spleens and LNs, whereas, the expression of Fas is absence in sections from normal healthy controls, as detected by immunofluorescent staining (Figure 4D, E) . These results suggest SARS-CoV-2 promotes lymphocyte apoptosis through enhancing Fas expression.

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