Author: Jillian N Whelan; Joshua Hatterschide; David M. Renner; Beihua Dong; Robert H Silverman; Susan R Weiss
Title: The host antiviral ribonuclease L protein supports Zika virus replication factory formation to enhance infectious virus production Document date: 2019_11_24
ID: f9mpkzni_40
Snippet: In this study, we present findings supporting a proviral role of the host RNase L protein, 378 which has otherwise been considered strictly antiviral. RNase L nucleolytic activity is 379 highly effective at restricting replication of a diverse range of DNA and RNA viruses 380 (Silverman, 2007) . However, catalytic activation of RNase L by ZIKV does not limit 381 infection, and instead ZIKV titers are paradoxically increased with RNase L expressio.....
Document: In this study, we present findings supporting a proviral role of the host RNase L protein, 378 which has otherwise been considered strictly antiviral. RNase L nucleolytic activity is 379 highly effective at restricting replication of a diverse range of DNA and RNA viruses 380 (Silverman, 2007) . However, catalytic activation of RNase L by ZIKV does not limit 381 infection, and instead ZIKV titers are paradoxically increased with RNase L expression. 382
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