Author: Wenhao Dai; Bing Zhang; Xia-Ming Jiang; Haixia Su; Jian Li; Yao Zhao; Xiong Xie; Zhenming Jin; Jingjing Peng; Fengjiang Liu; Chunpu Li; You Li; Fang Bai; Haofeng Wang; Xi Cheng; Xiaobo Cen; Shulei Hu; Xiuna Yang; Jiang Wang; Xiang Liu; Gengfu Xiao; Hualiang Jiang; Zihe Rao; Leike Zhang; Yechun Xu; Haitao Yang; Hong Liu
Title: Structure-Based Design, Synthesis and Biological Evaluation of Peptidomimetic Aldehydes as a Novel Series of Antiviral Drug Candidates Targeting the SARS-CoV-2 Main Protease Document date: 2020_3_28
ID: b4joa5tx_1
Snippet: sequence identify to SARS-CoV 4, 5, 6 . This novel coronavirus was named as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by the International Committee on Taxonomy of Viruses, and the pneumonia was designated as COVID-19 by the World Health Organization (WHO) on February 11, 2020 7 Coronaviruses are enveloped, positive-sense, single-stranded RNA viruses that lack the ability to correct errors occurring during RNA replication. This.....
Document: sequence identify to SARS-CoV 4, 5, 6 . This novel coronavirus was named as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by the International Committee on Taxonomy of Viruses, and the pneumonia was designated as COVID-19 by the World Health Organization (WHO) on February 11, 2020 7 Coronaviruses are enveloped, positive-sense, single-stranded RNA viruses that lack the ability to correct errors occurring during RNA replication. This property results in high variability of CoVs and mutations that occur frequently and quickly under environmental and evolutionary stress. Therefore, RNA CoVs are highly prevalent and severe pathogens of viral diseases 12 . The genomic RNA of CoVs is approximately 30 k nt in length with a 5'-cap structure and 3'-poly-A tail, which has the largest viral RNA genome known to date and contains at least 6 open reading frames (ORFs).
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