Author: Wenhao Dai; Bing Zhang; Xia-Ming Jiang; Haixia Su; Jian Li; Yao Zhao; Xiong Xie; Zhenming Jin; Jingjing Peng; Fengjiang Liu; Chunpu Li; You Li; Fang Bai; Haofeng Wang; Xi Cheng; Xiaobo Cen; Shulei Hu; Xiuna Yang; Jiang Wang; Xiang Liu; Gengfu Xiao; Hualiang Jiang; Zihe Rao; Leike Zhang; Yechun Xu; Haitao Yang; Hong Liu
Title: Structure-Based Design, Synthesis and Biological Evaluation of Peptidomimetic Aldehydes as a Novel Series of Antiviral Drug Candidates Targeting the SARS-CoV-2 Main Protease Document date: 2020_3_28
ID: b4joa5tx_28
Snippet: To explore the further druggability of the compounds 11a and 11b, both of two compounds were evaluated for its pharmacokinetic properties. As shown in Table S2 , compound 11a given intraperitoneally (5mg/kg) and intravenous (5mg/kg) displayed a long half-life (T 1/2 ) of 4.27 h and 4.41h, a high maximal concentration (C max =2394 author/funder. All rights reserved. No reuse allowed without permission......
Document: To explore the further druggability of the compounds 11a and 11b, both of two compounds were evaluated for its pharmacokinetic properties. As shown in Table S2 , compound 11a given intraperitoneally (5mg/kg) and intravenous (5mg/kg) displayed a long half-life (T 1/2 ) of 4.27 h and 4.41h, a high maximal concentration (C max =2394 author/funder. All rights reserved. No reuse allowed without permission.
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