Selected article for: "acute cardiac injury and heart failure acute cardiac injury"
Author: Lumbers, Eugenie R.; Delforce, Sarah J.; Pringle, Kirsty G.; Smith, Gary R.
Title: The Lung, the Heart, the Novel Coronavirus, and the Renin-Angiotensin System; The Need for Clinical Trials
  • Cord-id: tj7z3ocr
  • Document date: 2020_5_22
    • ID: tj7z3ocr
    Snippet: Angiotensin-converting enzyme 2 (ACE2) is the receptor for COVID-19 (SARs-CoV-2). ACE2 protects the lung and heart from acute respiratory distress syndrome (ARDS) and acute myocarditis and arrhythmias, because it breaks down Angiotensin II, which has inflammatory effects in the lung and heart as well as in the kidney. When SARS-CoV-2 binds to ACE2, it suppresses it, so this protective action of ACE2 is lost. Death from COVID-19 is due to ARDS and also heart failure and acute cardiac injury. Drug
    Document: Angiotensin-converting enzyme 2 (ACE2) is the receptor for COVID-19 (SARs-CoV-2). ACE2 protects the lung and heart from acute respiratory distress syndrome (ARDS) and acute myocarditis and arrhythmias, because it breaks down Angiotensin II, which has inflammatory effects in the lung and heart as well as in the kidney. When SARS-CoV-2 binds to ACE2, it suppresses it, so this protective action of ACE2 is lost. Death from COVID-19 is due to ARDS and also heart failure and acute cardiac injury. Drugs that prevent the inflammatory actions of Angiotensin II (i.e., Angiotensin receptor blockers, ARBs) prevent acute lung injury caused by SARS-CoV. Clinical trials are underway to test the risks and benefits of ARBs and angiotensin-converting enzyme inhibitors (ACEIs) in COVID-19 patients requiring hospitalization. Other potential treatments are also discussed.

    Search related documents:
    Co phrase search for related documents
    • ace activity and active peptide: 1
    • ace activity and activity affect: 1, 2
    • ace activity and acute ards respiratory distress syndrome: 1, 2, 3, 4, 5, 6, 7, 8
    • ace activity and acute cardiac injury: 1
    • ace enzyme and acid aspiration: 1
    • ace enzyme and active peptide: 1, 2
    • ace enzyme and activity affect: 1, 2
    • ace enzyme and acute ards respiratory distress syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • ace enzyme and acute cardiac injury: 1, 2, 3, 4, 5
    • ace inhibitor and acute ards respiratory distress syndrome: 1, 2, 3, 4
    • ace inhibitor and acute cardiac injury: 1, 2
    • acid aspiration and acute ards respiratory distress syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
    • active peptide and acute ards respiratory distress syndrome: 1
    • activity affect and acute ards respiratory distress syndrome: 1