Author: Jillian N Whelan; Joshua Hatterschide; David M. Renner; Beihua Dong; Robert H Silverman; Susan R Weiss
Title: The host antiviral ribonuclease L protein supports Zika virus replication factory formation to enhance infectious virus production Document date: 2019_11_24
ID: f9mpkzni_41
Snippet: In particular, a catalytically inactive form of RNase L improved ZIKV RF assembly and 383 function, thereby boosting virus production. We also provide evidence suggesting that 384 ZIKV repurposes the interaction between RNase L and the cytoskeleton to facilitate 385 rearrangement of the ER for establishment of ZIKV RFs. While cytoskeletal arrangements 386 for RF assembly within ER folds are characteristic of flaviviruses, we found that RNase L 38.....
Document: In particular, a catalytically inactive form of RNase L improved ZIKV RF assembly and 383 function, thereby boosting virus production. We also provide evidence suggesting that 384 ZIKV repurposes the interaction between RNase L and the cytoskeleton to facilitate 385 rearrangement of the ER for establishment of ZIKV RFs. While cytoskeletal arrangements 386 for RF assembly within ER folds are characteristic of flaviviruses, we found that RNase L 387 expression during DENV and KUNV infection had only minimal effects on RF formation. 388
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