Author: Jillian N Whelan; Joshua Hatterschide; David M. Renner; Beihua Dong; Robert H Silverman; Susan R Weiss
Title: The host antiviral ribonuclease L protein supports Zika virus replication factory formation to enhance infectious virus production Document date: 2019_11_24
ID: f9mpkzni_9
Snippet: RNase L-mediated cleavage of rRNA ( Figure 1B) . In contrast to other RNase L-activating 133 viruses, RNase L nuclease activity did not restrict ZIKV production. This was 134 demonstrated by a lack viral titer increase by 48hpi, after multiple rounds of replication, 135 in ZIKV-infected RNase L KO cells compared to in WT cells ( Figure 1C) . Instead, deletion 136 of RNase L reduced ZIKV production. In comparison to ZIKV, we detected weaker 137 ac.....
Document: RNase L-mediated cleavage of rRNA ( Figure 1B) . In contrast to other RNase L-activating 133 viruses, RNase L nuclease activity did not restrict ZIKV production. This was 134 demonstrated by a lack viral titer increase by 48hpi, after multiple rounds of replication, 135 in ZIKV-infected RNase L KO cells compared to in WT cells ( Figure 1C) . Instead, deletion 136 of RNase L reduced ZIKV production. In comparison to ZIKV, we detected weaker 137 activation of RNase L by West Nile virus Kunjin strain (KUNV), although also OAS3-138 All rights reserved. No reuse allowed without permission.
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